Doctor Odyssey Episode 12 has a powerhouse guest star lineup led by Shania Twain, Donna Mills, and Graham Rogers.
Love is in the air in the new episode of ABC's medical drama, "Sophisticated Ladies" as Tristan is determined to go all-in in making Avery fall in love with him.
While Tristan is busy in making a move, Max has to deal with the unexpected revelation that The Oddysey has a contagious passenger onboard.
Doctor Odyssey Episode 12 premiered on ABC on March 27.
Doctor Odyssey Episode 12 Cast Guide: Every Main Guest Star
Monette Moio - Brandi
Joining the cast of Doctor Odyssey Episode 12 is Monette Moio as Brandi, one of the passengers during the "Sophisticated Ladies" week of The Odyssey.
Moio is an actress and stunt performer best known for her roles in The Real Bros of Simi Valley: The Movie, Outer Range, and CSI: Vegas.
- Instagram: @monettemoio
- IMDb: Monette Moio
Nicola Bertram - Surgeon
Nicola Bertram plays a surgeon aboard The Odyssey in the brand-new episode of the ABC series.
Bertram also starred in Hollywood, Bosch: Legacy, and The Circle.
- Instagram: @nicolabertram2025
- IMDb: Nicola Bertram
Marcus Emanuel Mitchell - First Officer Spencer Monroe
Marcus Emanuel Mitchell returns as First Officer Spencer Monroe.
While he is still in recovery after being involved in a shark attack in Episode 9, Monroe is back aboard playing cards with the rest of the crew.
Mitchell can be seen in Step Up: High Water, High Strung, and Good Trouble.
- Instagram: @marcusemitchell
- IMDb: Marcus Emanuel Mitchell
Jaclyn Smith - Delia
Jaclyn Smith appears as part of the star-studded lineup of guests aboard The Odyssey in Doctor Odyssey Episode 12.
She portrays Delia, a passenger who is in remission after being diagnosed with cancer.
However, it is later revealed that it is all a lie because her cancer is still present, and she wants to hide it from her young boyfriend, Sam.
Smith has vast experience in the world of acting, having starred in the original Charlie's Angels series, The Adventurers, and The Bourne Identity.
- Instagram: @realjaclynsmith
- Wikipedia: Jaclyn Smith
- IMDb: Jaclyn Smith
Graham Rogers - Sam
One of the newcomers in Doctor Odyssey Episode 12 is Graham Rogers as Sam.
Sam is Delia's boyfriend and caretaker who has no idea that her cancer has returned.
Rogers can be seen in Atypical, Revolution, and The Kominsky Method. The actor is also part of the cast of High Potential Season 1, Episode 3.
- Instagram: @grahambamthankyoumam
- Wikipedia: Graham Rogers
- IMDb: Graham Rogers
Shania Twain - Heather
After making her debut as part of the cast of Doctor Odyssey Episode 2, Shania Twain returns as Heather in Episode 12.
Heather reunites with Captain Massey in Sophisticated Ladies Week, continuing their brief romance that started in Episode 2.
She then drops a bombshell to Captain Massey that she is
Twain is a singer-songwriter and actress known for her roles in A Man In Full, Monarch, and Broad City.
- Instagram: @shaniatwain
- Wikipedia: Shania Twain
- IMDb: Shania Twain
Donna Mills - Olivia
Appearing as a wealthy passenger aboard The Odyssey is Olivia, who is played on-screen by Donna Mills.
In Doctor Odyssey Episode 12, Olivia tests positive for COVID-19 during Sophisticated Ladies Week, but she insists that she doesn't want to be quarantined during her vacation.
Mills is best known for bringing Abby Ewing to life in Knots Landing.
The veteran actress can also be seen in Nope, Best Mom, and General Hospital.
Mills also recently appeared as a guest star in NCIS Season 22, Episode 3.
- Instagram: @thedonnamills
- Wikipedia: Donna Mills
- IMDb: Donna Mills
Here are the other main actors who appeared in Doctor Odyssey Episode 12:
- Joshua Jackson - Dr. Max Bankman
- Phillipa Soo - Nurse Avery Morgan
- Sean Teale - Nurse Tristan Silva
- Don Johnson - Captain Robert Massey
New episodes of Doctor Odyssey premiere on ABC at 9 p.m. ET every Thursday and can be streamed on Hulu the next day.
